Silver: Feces slow excretion rate Sulfadiazine: Urine (6.6% within 5 days) (Sano 1982) Half-Life Elimination Negligible (superficial and deep burns and normal skin) increased absorption with blister removal (Sano 1982) Excretion Active against Pseudomonas aeruginosa, Pseudomonas maltophilia, Enterobacter species, Klebsiella species, Serratia species, Escherichia coli, Proteus mirabilis, Morganella morganii, Providencia rettgeri, Proteus vulgaris, Providencia species, Citrobacter species, Acinetobacter calcoaceticus, Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus species, Candida albicans, Corynebacterium diphtheriae, and Clostridium perfringens Pharmacokinetics/Pharmacodynamics Absorption Bactericidal for many gram-negative and gram-positive bacteria and is effective against yeast. Acts upon the bacterial cell wall and cell membrane.
